Liquid Chromatography Mass Spectrometry (LC-MS) shares a strong link with the HPLC systems above. The LC-MS features improved pumps and injection systems enabling better accuracy and lower background .

The main difference between LC-MS and HPLC is the detection system; whereas HPLC-DAD uses absorption of visible and invisible light, the MS allows greater selectivity by basing its detection on the mass to charge ratio of the compound under investigation.Using a combination of radiofrequency mass filtering, only the ion of interest is allowed to reach the detector.This selectivity enables low level (part per billion, ppb) detection for a number of polar compounds that elsewise could not be detected.


  • Phenyl urea herbicides
  • Triazine herbicides
  • Sulfonylurea herbicides
  • Carbamate and N-methyl carbamate pesticides
  • Rodenticides
  • PFOS and its derivatives
  • Explosives
  • Di-isocyanates
  • Surfactants
  • Alkyl thioureas (low level)
  • Carbohydrates/sugars
  • Detergents
  • Ethanolamines
  • Phthalic acids
  • Sulphonamide antibiotics
  • Malachite/leucomalachite green
LCMS at i2 Analytical